top of page
The Sound of Evolution
Cyanocobalamin
氰鈷胺；維生素B12
Mechanism of action:
Cyanocobalamin 是一種維生素 B₁₂（vitamin B₁₂）的合成形式，屬於鈷胺類（cobalamin）化合物。Cyanocobalamin 本身是維生素 B₁₂ 的穩定前驅物，在體內會轉化為兩種具有生物活性的輔酶形式，甲基鈷胺（methylcobalamin）與腺苷鈷胺（adenosylcobalamin）。甲基鈷胺是甲硫胺酸合成酶（methionine synthase）的輔酶，與 DNA 合成和紅血球成熟有關；而腺苷鈷胺是甲基丙二酸單醯輔酶A變位酶（methylmalonyl coenzyme-A mutase）的輔酶，與脂肪酸和胺基酸代謝有關。
Reference(s):
1. Wickramasinghe SN et al. (1995). Morphology, biology and biochemistry of cobalamin- and folate-deficient bone marrow cells. Baillieres Clin Haematol.
2. Sharabi A et al. (2003). Replacement therapy for vitamin B12 deficiency: comparison between the sublingual and oral route. Br J Clin Pharmacol.
3. Hall AH et al. (1987). Hydroxycobalamin/sodium thiosulfate as a cyanide antidote. J Emerg Med.
bottom of page