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Cycloserine

環絲氨酸

Mechanism of action:

Cycloserine 是一種胺基酸類抗生素（amino acid analog antibiotic）。Cycloserine 能抑制 D-丙胺酸消旋酶（D-alanine racemase）活性，使 L-alanine 無法轉化為 D-alanine，D-alanine 是細菌細胞壁肽聚糖（peptidoglycan）的成分之一。Cycloserine 也能抑制 D-丙胺酸-D-丙胺酸連接酶（D-alanine-D-alanine ligase）的活性，讓 D-alanine-D-alanine 無法生成，同樣阻止肽聚糖的生成。

​Reference(s):

1. Belanger AE et al. (2000). Genetic analysis of peptidoglycan biosynthesis in mycobacteria: characterization of a ddlA mutant of Mycobacterium smegmatis. J Bacteriol. 


2. Noda M et al. (2004). Self-protection mechanism in D-cycloserine-producing Streptomyces lavendulae: gene cloning, characterization, and kinetics of its alanine racemase and D-alanyl-D-alanine ligase, which are target enzymes of D-cycloserine. J Biol Chem.

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