top of page
< Back

Cyproheptadine

塞浦西他啶

Mechanism of action:

Cyproheptadine 是一種第一代 H₁ 受體拮抗劑（first-generation H₁ antihistamine）。Cyproheptadine 結合於 H₁ 受體，使組織胺（histamine）無法與 H₁ 受體結合，阻止組織胺引起的微血管擴張、血管通透性上升與平滑肌收縮。Cyproheptadine 也是血清素 5-HT₂ 受體拮抗劑，可抑制血清素引起的血管收縮與食慾抑制作用。

​Reference(s):

1. Tokunaga S et al. (2007). Effects of some H1-antagonists on the sleep-wake cycle in sleep-disturbed rats. J Pharmacol Sci. 


2. Milani N et al. (2020). Use of phenotypically poor metabolizer individual donor human liver microsomes to identify selective substrates of UGT2B10. Drug Metab Dispos.

bottom of page