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Cytarabine

阿糖胞苷

Mechanism of action:

Cytarabine 是一種嘧啶核苷（pyrimidine nucleoside）類似物。Cytarabine 的結構類似胞苷（cytidine），但其糖基為阿拉伯糖（arabinose）而非核糖（ribose）。Cytarabine 本身為前驅物，需經細胞內的酵素磷酸化為 cytarabine triphosphate 才有藥理作用。Cytarabine triphosphate 會與 dCTP 競爭性結合至 DNA 聚合酶，並可被摻入 DNA 造成鏈延長受阻，導致 DNA 合成中止，最後引發細胞凋亡。

​Reference(s):

1. Angeli JP et al. (2006). Anti-clastogenic effect of beta-glucan extracted from barley towards chemically induced DNA damage in rodent cells. Hum Exp Toxicol. 


2. Prakasha Gowda AS et al. (2010). Incorporation of gemcitabine and cytarabine into DNA by DNA polymerase beta and ligase III/XRCC1. Biochemistry. 


3. Zhou Y et al. (2024). TTD: Therapeutic Target Database describing target druggability information. Nucleic Acids Res.

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