top of page
< Back

Darbepoetin

達依泊汀

Mechanism of action:

Darbepoetin 是一種重組的人類紅血球生成素（recombinant human erythropoietin）。Darbepoetin 能結合於紅血球祖細胞（erythroid progenitor cells）上的紅血球生成素受體（erythropoietin receptor）。該受體活化後，啟動 JAK2-STAT5 訊號傳導路徑，促進細胞存活與分化。Darbepoetin 也會藉由同樣的受體促進骨髓內 BFU-E（burst-forming unit-erythroid）與 CFU-E（colony-forming unit-erythroid）兩種紅血球原始細胞分化成熟，增加網狀紅血球（reticulocyte）的產生，進而提升外週血的紅血球數量與血紅素（Hb）濃度。

​Reference(s):

1. LaMontagne KR et al. (2006). Recombinant epoetins do not stimulate tumor growth in erythropoietin receptor-positive breast carcinoma models. Mol Cancer Ther. 


2. Kokhaei P et al. (2007). Expression of erythropoietin receptor and in vitro functional effects of epoetins in B-cell malignancies. Clin Cancer Res. 


3. Chen X et al. (2002). TTD: Therapeutic Target Database. Nucleic Acids Res.

bottom of page