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Deoxycorticosterone

11-脫氧皮質酮

Mechanism of action:

Deoxycorticosterone 是一種腎上腺皮質類固醇(adrenocortical steroid),屬於鹽皮質激素(mineralocorticoid)類。它主要由腎上腺皮質小球區(zona glomerulosa)合成與分泌。Deoxycorticosterone 進入腎臟遠曲小管與集尿小管的上皮細胞內,和鹽皮質激素受體(mineralocorticoid receptor)結合後,能促進上皮鈉離子通道(ENaC)與鈉鉀幫浦(Na⁺/K⁺-ATPase)的表達,增強鈉離子再吸收與鉀離子排出,產生保鈉、排鉀的生理作用。

​Reference(s):

Lu NZ et al. (2006). International Union of Pharmacology. LXV. The pharmacology and classification of the nuclear receptor superfamily: glucocorticoid, mineralocorticoid, progesterone, and androgen receptors. Pharmacol Rev.

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