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Desvenlafaxine

去甲文拉法辛

Mechanism of action:

Desvenlafaxine 是一種血清素-正甲腎上腺素回收抑制劑（serotonin-norepinephrine reuptake inhibitor）。Desvenlafaxine 能抑制血清素轉運體（serotonin transporter）活性，導致血清素無法從突觸間隙回收，而強化血清素作用，進而調節與情緒、焦慮反應及睡眠調控相關的中樞神經傳導路徑；也會抑制正腎上腺素轉運體（norepinephrine transporter）活性，同樣阻止正腎上腺素回收，調控與動機、注意力與警覺性相關的神經訊號傳遞。

​Reference(s):

1. Pae CU et al. (2011). Desvenlafaxine in the treatment of major depressive disorder. Expert Opin Pharmacother. 


2. Ilett KF et al. (2010). Assessment of infant dose through milk in a lactating woman taking amisulpride and desvenlafaxine for treatment-resistant depression. Ther Drug Monit.

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