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Diazepam

地西泮

Mechanism of action:

Diazepam 是一種苯二氮平類（benzodiazepine）衍生物。Diazepam 會結合於 GABA_A 受體的苯二氮平結合位點（benzodiazepine-binding site），增加 GABA_A 受體的抑制作用，使氯離子通道開啟頻率上升，導致氯離子流入神經元，引起膜超極化（hyperpolarization），可產生抗焦慮、鎮靜與催眠、抗痙攣等中樞神經抑制相關作用。

​Reference(s):

1. Mant A et al. (1993). Benzodiazepine utilisation in Australia: report from a new pharmacoepidemiological database. Aust J Public Health. 


2. Earley JV et al. (1979). Quinazolines and 1,4-benzodiazepines. LXXXIX: Haptens useful in benzodiazepine immunoassay development. J Pharm Sci. 


3. Usami N et al. (2002). Substrate specificity of human 3(20)alpha-hydroxysteroid dehydrogenase for neurosteroids and its inhibition by benzodiazepines. Biol Pharm Bull.

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