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Dibucaine

地布卡因

Mechanism of action:

Dibucaine 是一種醯胺類（amide）衍生物。Dibucaine 能在神經細胞膜內側結合鈉離子通道蛋白，抑制動作電位的去極化階段（depolarization）阻止神經動作電位的產生與傳導，導致局部感覺喪失（麻木），尤其是疼痛與溫覺。

​Reference(s):

1. Abdel-Ghani NT et al. (2005). Cinchocaine hydrochloride determination by atomic absorption spectrometry and spectrophotometry. Farmaco. 


2. Souto-Padron T et al. (2006). Effects of dibucaine on the endocytic/exocytic pathways in Trypanosoma cruzi. Parasitol Res. 


3. Nounou MM et al. (2005). Effect of various formulation variables on the encapsulation and stability of dibucaine base in multilamellar vesicles. Acta Pol Pharm.

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