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Diethylcarbamazine

乙胺嗪

Mechanism of action:

Diethylcarbamazine 是一種哌𠯤（piperazine）衍生物。Diethylcarbamazine 的確切機制尚未完全明瞭，但可能使微絲蟲（microfilaria）表面結構受損，改變絲蟲表面膜通透性，促進宿主免疫系統辨識與清除。此外，也可能影響花生四烯酸（arachidonic acid）的代謝，抑制寄生蟲防禦宿主免疫反應的能力，使宿主的吞噬細胞（macrophage）與嗜酸性球（eosinophil）能更有效攻擊寄生蟲。

​Reference(s):

1. Bach MK et al. (1986). Inhibition of the leukotriene synthetase of rat basophil leukemia cells by diethylcarbamazine, and synergism between diethylcarbamazine and piriprost, a 5-lipoxygenase inhibitor. Biochem Pharmacol. 


2. Cernak I et al. (1996). Leukotrienes in the pathogenesis of pulmonary blast injury. J Trauma.

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