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Disulfiram

雙硫侖

Mechanism of action:

Disulfiram 屬於二硫化秋蘭姆（thiuram disulfide）的衍生物。Disulfiram 會抑制乙醛去氫酶（acetaldehyde dehydrogenase）的活性，導致乙醇攝入後轉變成乙醛時無法代謝，在血液中大量累積。當體內乙醛濃度升高，會引起面部潮紅、劇烈頭痛、噁心、嘔吐、呼吸困難、出汗，嚴重者可導致心律不整、循環衰竭甚至具潛在致命風險，這種不愉快的反應可形成對飲酒行為的負向條件作用，作為行為層面的抑制因素。

​Reference(s):

1. Nash T et al. (1998). Efficacies of zinc-finger-active drugs against Giardia lamblia. Antimicrob Agents Chemother. 


2. Bouma MJ et al. (1998). Activity of disulfiram (bis(diethylthiocarbamoyl)disulphide) and ditiocarb (diethyldithiocarbamate) against metronidazole-sensitive and -resistant Trichomonas vaginalis and Tritrichomonas foetus. J Antimicrob Chemother.

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