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Divalproex

二丙戊酸

Mechanism of action:

Divalproex 是一種丙戊酸類（valproic acid）衍生物。Divalproex 能抑制 GABA 轉胺酶（GABA transaminase）與琥珀酸半醛去氫酶（succinic semialdehyde dehydrogenase），減少 GABA 分解，使 GABA 濃度上升；同時可能促進 GABA 合成。結果能增強抑制性神經傳導、降低神經元過度興奮的傾向。

​Reference(s):

1. Rosenberg G et al. (2007). The mechanisms of action of valproate in neuropsychiatric disorders: can we see the forest for the trees? Cell Mol Life Sci. 


2. Lehrman G et al. (2005). Depletion of latent HIV-1 infection in vivo: a proof-of-concept study. Lancet.

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