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The Sound of Evolution
Dolasetron
多拉司瓊
Mechanism of action:
Dolasetron 是一種選擇性 5-HT₃ 受體拮抗劑（selective serotonin 5-HT₃ receptor antagonist）。化療或麻醉刺激腸胃黏膜時，腸嗜鉻細胞（enterochromaffin cell）會釋放大量血清素（serotonin，5-HT），作用於迷走神經末端與延腦的化學受體觸發區（chemoreceptor trigger zone，CTZ），引起噁心、嘔吐。Dolasetron 透過競爭性拮抗 5-HT₃ 受體，阻止血清素活化這些神經路徑，從而抑制噁心與嘔吐反射。
Reference(s):
1. Balfour JA et al. (1997). Dolasetron. A review of its pharmacology and therapeutic potential in the management of nausea and vomiting induced by chemotherapy, radiotherapy or surgery. Drugs.
2. Gregory RE et al. (1998). 5-HT3 receptor antagonists for the prevention of chemotherapy-induced nausea and vomiting: a comparison of their pharmacology and clinical efficacy. Drugs.
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