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Doripenem

多尼培南

Mechanism of action:

Doripenem 是一種 β-內醯胺類抗生素（β-lactam antibiotic），屬於碳青黴烯類（carbapenem）。Doripenem 的 β-內醯胺（β-lactam）環可與細菌的青黴素結合蛋白（penicillin-binding proteins，PBPs）結合，抑制其轉肽酶（transpeptidase）活性，使肽聚醣（peptidoglycan）鏈無法交聯，最後細胞壁結構脆弱，因滲透壓而讓細菌破裂死亡。

​Reference(s):

1. Jones RN et al. (2004). Activities of doripenem (S-4661) against drug-resistant clinical pathogens. Antimicrob Agents Chemother. 


2. Chahine EB et al. (2010). Doripenem: a new carbapenem antibiotic. Am J Health Syst Pharm. 


3. Dedhia HV et al. (2009). Doripenem: position in clinical practice. Expert Rev Anti Infect Ther.

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