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The Sound of Evolution
Dorzolamide
杜塞醯胺
Mechanism of action:
Dorzolamide 是一種碳酸酐酶抑制劑（carbonic anhydrase inhibitor）。碳酸酐酶 II 存在於眼睛的睫狀體（ciliary body）上皮細胞，能催化生成碳酸氫根（HCO₃⁻），是房水（aqueous humor）生成的關鍵成分。Dorzolamide 抑制碳酸酐酶 II 後，導致房水分泌減少、眼內壓下降。
Reference(s):
1. Martens-Lobenhoffer J et al. (2002). Clinical pharmacokinetics of dorzolamide. Clin Pharmacokinet.
2. Balfour JA et al. (1997). Dorzolamide. A review of its pharmacology and therapeutic potential in the management of glaucoma and ocular hypertension. Drugs Aging.
3. Arieta C et al. (2002). Dorzolamide versus apraclonidine in the prevention of the intraocular pressure spike after Nd:YAG laser posterior capsulotomy. Curr Eye Res.
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