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Doxycycline

多西環素

Mechanism of action:

Doxycycline 是一種四環黴素類抗生素（tetracycline antibiotic）。Doxycycline 能可逆性結合於細菌核糖體的 30S 亞基，阻止氨醯-tRNA（aminoacyl-tRNA）與 mRNA-核糖體複合體結合，使新的胺基酸無法加入肽鏈，導致蛋白質無法生成。

​Reference(s):

1. Hoerauf A et al. (2003). Doxycycline as a novel strategy against bancroftian filariasis: depletion of Wolbachia endosymbionts from Wuchereria bancrofti and stop of microfilaria production. Med Microbiol Immunol. 


2. Taylor MJ et al. (2005). Macrofilaricidal activity after doxycycline treatment of Wuchereria bancrofti: a double-blind, randomised placebo-controlled trial. Lancet.

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