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Emtricitabine

恩曲他濱

Mechanism of action:

Emtricitabine 是一種核苷類反轉錄酶抑制劑（nucleoside reverse transcriptase inhibitor）， 為胞苷（cytidine）類似物。當 emtricitabine 進入細胞後，會經宿主細胞的酵素磷酸化，轉換為有活性的 emtricitabine triphosphate。Emtricitabine triphosphate 會與 dCTP（deoxycytidine triphosphate）競爭，有機會被 HIV 反轉錄酶誤納入正在合成的病毒 DNA 中，造成 DNA 合成終止，使病毒無法完成反轉錄並進行後續複製。

​Reference(s):

1. Shockcor JP et al. (1996). HPLC-NMR identification of the human urinary metabolites of (−)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl] cytosine, a nucleoside analogue active against human immunodeficiency virus (HIV). Xenobiotica. 


2. Valade E et al. (2014). Population pharmacokinetics of emtricitabine in HIV-1-infected adult patients. Antimicrob Agents Chemother.

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