top of page
< Back

Ergocalciferol

麥角鈣化醇；維生素D2

Mechanism of action:

Ergocalciferol 是維生素 D₂。Ergocalciferol 在肝臟中經 25-羥化酶（25-hydroxylase）轉化為25-hydroxyvitamin D₂（25(OH)D₂），進一步在腎臟經 1α-羥化酶（1α-hydroxylase）轉化為生理活性形式的 1,25-dihydroxyvitamin D₂，能與維生素 D 受體（vitamin D receptor）結合，調控多種基因轉錄，促進腸道鈣與磷的吸收、維持血鈣與血磷平衡、支持骨礦化相關的生理調控。

​Reference(s):

1. Porter A et al. (2013). Prevalence of 25-OH vitamin D deficiency in a population of hemodialysis patients and efficacy of an oral ergocalciferol supplementation regimen. Am J Nephrol. 


2. Lee JY et al. (2013). A review on vitamin d deficiency treatment in pediatric patients. J Pediatr Pharmacol Ther.

bottom of page