top of page
The Sound of Evolution
Escitalopram
艾司西酞普蘭
Mechanism of action:
Escitalopram 是一種選擇性血清素再回收抑制劑（selective serotonin reuptake inhibitor），為西酞普蘭（citalopram）的 S-對映異構物（S-enantiomer）。Escitalopram 會高親和力結合突觸前神經元膜上的血清素轉運蛋白（serotonin transporter），阻斷血清素（5-HT）由突觸間隙回收至神經元內。血清素在突觸間隙停留時間延長、濃度上升，增強突觸後 5-HT 受體的活化，進而調節與情緒、焦慮及強迫相關的神經路徑活動。
Reference(s):
1. Moore N et al. (2005). Prospective, multicentre, randomized, double-blind study of the efficacy of escitalopram versus citalopram in outpatient treatment of major depressive disorder. Int Clin Psychopharmacol.
2. Boulenger JP et al. (2006). A comparative study of the efficacy of long-term treatment with escitalopram and paroxetine in severely depressed patients. Curr Med Res Opin.
bottom of page