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The Sound of Evolution
Esomeprazole
埃索美拉唑
Mechanism of action:
Esomeprazole 是一種質子幫浦抑制劑（proton pump inhibitor），為 omeprazole 的 S-對映異構物（S-enantiomer）。Esomeprazole 在胃中被活化為帶有次磺醯胺（sulfenamide）的形式，之後與胃壁細胞中的氫鉀幫浦（H⁺/K⁺-ATPase）形成共價鍵，不可逆地抑制氫鉀幫浦活性，阻斷氫離子分泌至胃腔中。
Reference(s):
1. Lind T et al. (2000). Esomeprazole provides improved acid control vs. omeprazole in patients with symptoms of gastro-oesophageal reflux disease. Aliment Pharmacol Ther.
2. Klotz U et al. (2006). Clinical impact of CYP2C19 polymorphism on the action of proton pump inhibitors: a review of a special problem. Int J Clin Pharmacol Ther.
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