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Etomidate

依托咪酯

Mechanism of action:

Etomidate 為 GABA_A 受體的正向變構調節劑（positive allosteric modulator），可增強 GABA 與其受體的作用，增加氯離子通道（Cl⁻ channel）開啟機率，使神經元膜電位超極化（hyperpolarization），降低神經元興奮性。

​Reference(s):

1. Martin LJ et al. (2009). Etomidate targets alpha5 gamma-aminobutyric acid subtype A receptors to regulate synaptic plasticity and memory blockade. Anesthesiology. 


2. Desai R et al. (2009). Gamma-amino butyric acid type A receptor mutations at beta2N265 alter etomidate efficacy while preserving basal and agonist-dependent activity. Anesthesiology.

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