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Etonogestrel

依託孕烯
Mechanism of action:
Etonogestrel 是一種合成黃體素(synthetic progestin),屬於第三代黃體製劑。Etonogestrel 會提供穩定的黃體訊號,對下視丘-腦下垂體-卵巢 軸(H-P-O axis)產生負回饋,抑制黃體成長激素(LH)達到高峰(LH surge),使排卵受到抑制。也會使子宮頸黏液變得濃稠,降低精子進入子宮腔的能力;使子宮內膜維持在不利於著床的狀態,進一步降低受精與著床的機率。
Reference(s):
1. Gariepy AM et al. (2015). Cost-effectiveness of immediate compared with delayed postpartum etonogestrel implant insertion. Obstet Gynecol.
2. Roumen FJ et al. (2008). Review of the combined contraceptive vaginal ring, NuvaRing. Ther Clin Risk Manag.
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