top of page
< Back

Everolimus

依維莫司

Mechanism of action:

Everolimus 是一種 mTOR 抑制劑（mammalian target of rapamycin inhibitor），為雷帕黴素（rapamycin）的衍生物。Everolimus 會先與細胞內的 FKBP-12（FK506-binding protein 12）結合，形成 Everolimus-FKBP-12 複合體。該複合體會抑制 mTORC1 的激酶活性，阻斷下游訊號分子磷酸化，使細胞週期停滯於 G1 期，抑制細胞增殖。

​Reference(s):

1. Kuhn B et al. (2001). Metabolism of sirolimus and its derivative everolimus by cytochrome P450 3A4: insights from docking, molecular dynamics, and quantum chemical calculations. J Med Chem. 


2. Krueger DA et al. (2010). Everolimus for subependymal giant-cell astrocytomas in tuberous sclerosis. N Engl J Med.

bottom of page