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Exemestane

依西美坦

Mechanism of action:

Exemestane 是一種芳香化酶抑制劑（aromatase inhibitor）。Exemestane 的結構類似雄烯二酮（androstenedione），可進入芳香化酶的活性位點，會形成共價結合，不可逆抑制芳香化酶的活性。芳香化酶被抑制後，雌二醇（estradiol）與雌酮（estrone）濃度顯著下降，減少雌激素對乳癌細胞的刺激。

​Reference(s):

1. Coombes RC et al. (2007). Survival and safety of exemestane versus tamoxifen after 2–3 years' tamoxifen treatment (Intergroup Exemestane Study): a randomised controlled trial. Lancet. 


2. Robinson A et al. (2009). A review of the use of exemestane in early breast cancer. Ther Clin Risk Manag.

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