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Exenatide

艾塞那肽

Mechanism of action:

Exenatide 是一種類升糖素胜肽-1 受體促效劑（glucagon-like peptide-1 receptor agonist）。Exenatide 藉由與胰島 β 細胞上的 GLP-1 受體結合，促進葡萄糖依賴性的胰島素分泌，同時抑制升糖素釋放、延緩胃排空，並影響中樞食慾調控路徑；整體使血糖調控相關訊號偏向下降。

​Reference(s):

1. Gao W et al. (2012). Target-mediated pharmacokinetic and pharmacodynamic model of exendin-4 in rats, monkeys, and humans. Drug Metab Dispos. 


2. Copley K et al. (2006). Investigation of exenatide elimination and its in vivo and in vitro degradation. Curr Drug Metab.

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