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Famotidine

法莫替丁

Mechanism of action:

Famotidine 是一種組織胺 H₂ 受體拮抗劑（histamine H₂-receptor antagonist）。Famotidine 在胃壁細胞（parietal cell）上競爭性拮抗 H₂ 受體，阻止組織胺結合 H₂ 受體，使cAMP 介導的胃酸分泌活化訊號下降，從而使氫鉀幫浦（H⁺/K⁺-ATPase）被啟動的程度降低，進而抑制胃酸分泌。

​Reference(s):

1. Chremos AN et al. (1987). Clinical pharmacology of famotidine: a summary. J Clin Gastroenterol. 


2. Langtry HD et al. (1989). Famotidine. An updated review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in peptic ulcer disease and other allied diseases. Drugs.

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