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Fenofibrate

非諾貝特

Mechanism of action:

Fenofibrate 是一種纖維酸衍生物（fibrate）。Fenofibrate 在體內轉化為 fenofibric acid 後會和 PPAR-α 結合，調控多種與脂質代謝相關的基因轉錄。提升脂蛋白解脂酶（lipoprotein lipase）表達量，加速極低密度脂蛋白（VLDL）與乳糜微粒中三酸甘油脂的分解，並促進脂肪酸氧化相關路徑。

​Reference(s):

1. Wei X et al. (2017). Absolute oral bioavailability of fenofibric acid and choline fenofibrate in rats determined by ultra-performance liquid chromatography tandem mass spectrometry. Biomed Chromatogr. 


2. Chapman MJ et al. (1987). Pharmacology of fenofibrate. Am J Med.

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