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Fenoprofen

菲諾洛芬

Mechanism of action:

Fenoprofen 是一種丙酸類（propionic acid）衍生物。Fenoprofen 能抑制環氧化酶（cyclooxygenase），包含 COX-1 與 COX-2，阻止將花生四烯酸（arachidonic acid）轉換為前列腺素（prostaglandin），降低前列腺素介導的發炎訊號、痛覺敏感化與發燒反應。

​Reference(s):

1. Poggi JC et al. (2006). Pharmacodynamics, chiral pharmacokinetics, and pharmacokinetic-pharmacodynamic modeling of fenoprofen in patients with diabetes mellitus. J Clin Pharmacol. 


2. Zhou Y et al. (2024). TTD: Therapeutic Target Database describing target druggability information. Nucleic Acids Res.

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