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Ferrous sulfate

硫酸亞鐵

Mechanism of action:

Ferrous sulfate 於腸道溶解後釋放 Fe²⁺，在十二指腸與近端空腸透過 DMT1（divalent metal transporter 1）被腸上皮細胞吸收。Fe²⁺ 進入腸上皮細胞後，可經由 ferroportin 輸出至血液側，並在輸出過程中被氧化為 Fe³⁺，再與運鐵蛋白（transferrin）結合，經血液運送至骨髓、肝臟與其他組織。

​Reference(s):

1. Leary A et al. (2016). Pharmacokinetics of ferrous sulphate (Tardyferon®) after single oral dose administration in women with iron deficiency anaemia. Drug Res (Stuttg). 


2. Conrad ME et al. (2000). Separate pathways for cellular uptake of ferric and ferrous iron. Am J Physiol Gastrointest Liver Physiol.

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