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Fesoterodine

非索羅定

Mechanism of action:

Fesoterodine 是一種抗毒蕈鹼（antimuscarinic agent）分子。Fesoterodine 進入體內後迅速轉化為其主要活性代謝物 5-hydroxymethyl tolterodine（5-HMT），能拮抗膀胱平滑肌上的毒蕈鹼型乙醯膽鹼受體（muscarinic acetylcholine receptor），主要為 M₃，抑制逼尿肌非自主性收縮。

​Reference(s):

1. Malhotra B et al. (2011). Effects of the moderate CYP3A4 inhibitor, fluconazole, on the pharmacokinetics of fesoterodine in healthy subjects. Br J Clin Pharmacol. 


2. Malhotra B et al. (2009). The design and development of fesoterodine as a prodrug of 5-hydroxymethyl tolterodine (5-HMT), the active metabolite of tolterodine. Curr Med Chem.

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