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Fluconazole

氟康唑

Mechanism of action:

Fluconazole 是一種三唑類（triazole）衍生物。Fluconazole 能抑制黴菌的羊毛甾醇-14α-脫甲基酶（lanosterol 14α-demethylase，CYP51），該酵素負責將羊毛固醇（lanosterol）轉化為麥角固醇（ergosterol）。當此步驟被阻斷，黴菌的細胞膜結構會變得不完整，且羊毛固醇因為無法轉化而不斷堆積，引起毒性，最終讓真菌生長受抑或死亡。

​Reference(s):

1. Bongomin F et al. (2018). A systematic review of fluconazole resistance in clinical isolates of Cryptococcus species. Mycoses. 


2. Hollier LM et al. (1995). Fluconazole (Diflucan). Infect Dis Obstet Gynecol. 


3. Allen D et al. (2015). Azole antifungals: 35 years of invasive fungal infection management. Expert Rev Anti Infect Ther.

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