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Fludarabine

氟達拉濱

Mechanism of action:

Fludarabine 是一種氟化嘌呤核苷（fluorinated purine nucleoside）類似物。Fludarabine 進入細胞後，先轉化為氟達拉濱單磷酸（fludarabine monophosphate），再經細胞的激酶磷酸化為氟達拉濱三磷酸（fludarabine triphosphate），此為主要的活性抗癌形式。氟達拉濱三磷酸能抑制多個與 DNA 合成相關的關鍵酵素，包含 DNA 聚合酶-α、δ、ε、核糖核苷酸還原酶（ribonucleotide reductase）、DNA 引發酶（DNA primase）等，使細胞的 DNA 合成異常，最後導致細胞凋亡。

​Reference(s):

1. Rai KR et al. (2000). Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia. N Engl J Med. 


2. Gonzalez H et al. (1998). Severe autoimmune hemolytic anemia in eight patients treated with fludarabine. Hematol Cell Ther. 


3. Tournilhac O et al. (2004). Impact of frontline fludarabine and cyclophosphamide combined treatment on peripheral blood stem cell mobilization in B-cell chronic lymphocytic leukemia. Blood.

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