top of page
< Back

Flurbiprofen

氟比洛芬

Mechanism of action:

Flurbiprofen 是一種丙酸類（propionic acid）衍生物。Flurbiprofen 能抑制環氧化酶（cyclooxygenase），包含 COX-1 與 COX-2，阻止將花生四烯酸（arachidonic acid）轉換為前列腺素（prostaglandin），降低前列腺素介導的發炎訊號、痛覺敏感化與發燒反應。

​Reference(s):

1. Geerts H et al. (2007). Drug evaluation: (R)-flurbiprofen—an enantiomer of flurbiprofen for the treatment of Alzheimer's disease. IDrugs. 


2. Zhou SF et al. (2009). Substrates, inducers, inhibitors and structure-activity relationships of human cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 


3. Calapai G et al. (2013). Fatal hypersensitivity reaction to an oral spray of flurbiprofen: a case report. J Clin Pharm Ther.

bottom of page