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Fluticasone

氟替卡松

Mechanism of action:

Fluticasone 是一種糖皮質類固醇（inhaled corticosteroid）。Fluticasone 進入細胞，與糖皮質類固醇受體（glucocorticoid receptor）結合，而藥物-受體複合體隨後移入細胞核，提升抗發炎基因（如 annexin A1）的表達；抑制發炎相關轉錄因子（如 NF-κB、AP-1）等。

​Reference(s):

1. Allen A et al. (2013). Fluticasone furoate, a novel inhaled corticosteroid, demonstrates prolonged lung absorption kinetics in man compared with inhaled fluticasone propionate. Clin Pharmacokinet. 


2. Allen A et al. (2013). Inhaled fluticasone furoate/vilanterol does not affect hypothalamic-pituitary-adrenal axis function in adolescent and adult asthma: randomised, double-blind, placebo-controlled study. Clin Respir J. 


3. Phillipps GH et al. (1990). Structure-activity relationships of topically active steroids: the selection of fluticasone propionate. Respir Med.

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