The Sound of Evolution
Fosamprenavir
福沙那韋
Mechanism of action:
Fosamprenavir 是一種 HIV 蛋白酶抑制劑安普那韋（amprenavir）的前驅藥（protease inhibitor prodrug）。Fosamprenavir 在腸道與肝臟中被鹼性磷酸酶（alkaline phosphatase）水解，轉化為其活性型態 amprenavir。Amprenavir 可選擇性結合於 HIV-1 蛋白酶的活性位點，阻斷該酵素對 Gag 與 Gag-Pol 多蛋白前驅物（polyproteins）的切割，使病毒結構不完整且無感染能力。
Reference(s):
1. Smith KY et al. (2008). Fosamprenavir or atazanavir once daily boosted with ritonavir 100 mg, plus tenofovir/emtricitabine, for the initial treatment of HIV infection: 48-week results of ALERT. AIDS Res Ther.
2. Hoffman RM et al. (2007). Evaluation of sex differences of fosamprenavir (with and without ritonavir) in HIV-infected men and women. HIV Clin Trials.
3. Chapman TM et al. (2004). Fosamprenavir: a review of its use in the management of antiretroviral therapy-naive patients with HIV infection. Drugs.