top of page
The Sound of Evolution
Fosinopril
福辛普利
Mechanism of action:
Fosinopril 是一種血管張力素轉化酶抑制劑（angiotensin-converting enzyme inhibitor），屬於福辛普利拉（fosinoprilat）的前驅藥。Fosinopril 在肝臟與腸道被水解成活性型態的 fosinoprilat，會競爭性抑制血管張力素轉化酶（angiotensin-converting enzyme），阻斷血管張力素 I（angiotensin I）轉化為血管張力素 II（angiotensin II），使血管收縮減弱、醛固酮（aldosterone）分泌下降、鈉與水的滯留減少，血容量下降、週邊血管阻力與循環負荷下降。
Reference(s):
1. David D et al. (1995). A comparison of the cough profile of fosinopril and enalapril in hypertensive patients with a history of ACE inhibitor-associated cough. Am J Ther.
2. Sharma S et al. (1999). The hemodynamic effects of long-term ACE inhibition with fosinopril in patients with heart failure. Am J Ther.
bottom of page