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The Sound of Evolution
Gabapentin
加巴噴丁
Mechanism of action:
Gabapentin 是一種 γ-胺基丁酸（GABA）結構類似物。Gabapentin 會高親和力結合於電壓門控鈣離子通道（voltage-gated Ca²⁺ channel）的 α₂δ-1 與 α₂δ-2 亞基。這些亞基主要存在於 中樞與週邊神經的突觸前神經元。當神經元去極化時，gabapentin 會降低鈣離子經鈣離子通道進入細胞的量，抑制神經傳導物質釋放，降低神經元過度放電與痛覺相關訊號的突觸傳遞。
Reference(s):
1. Yagi T et al. (2012). Impact of concomitant antacid administration on gabapentin plasma exposure and oral bioavailability in healthy adult subjects. Drug Metab Pharmacokinet.
2. Czapinski P et al. (2005). Mechanisms of action of antiepileptic drugs. Curr Top Med Chem.
3. Patsalos PN et al. (2008). Antiepileptic drugs--best practice guidelines for therapeutic drug monitoring: a position paper by the subcommission on therapeutic drug monitoring, ILAE Commission on Therapeutic Strategies. Epilepsia.
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