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Gentamicin

慶大黴素

Mechanism of action:

Gentamicin 是一種胺基醣苷類抗生素（aminoglycoside antibiotic）。Gentamicin 能不可逆地結合於 30S 核糖體亞基，影響 mRNA 的正確解讀，導致錯誤胺基酸被摻入蛋白質，生成異常或無功能蛋白質。

​Reference(s):

1. Siber GR et al. (1975). Pharmacokinetics of gentamicin in children and adults. J Infect Dis. 


2. Jones TE et al. (2009). Aminoglycoside clearance is a good estimate of creatinine clearance in intensive care unit patients. Anaesth Intensive Care. 


3. Ahmed RM et al. (2012). Gentamicin ototoxicity: a 23-year selected case series of 103 patients. Med J Aust.

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