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Guanabenz

胍那苄

Mechanism of action:

Guanabenz 屬於 α₂-腎上腺素受體促效劑（α₂-adrenergic agonist）。Guanabenz 能活化腦幹（特別是延腦血管運動中樞）的 α₂ 受體，抑制正腎上腺素（norepinephrine）的釋放，降低交感神經對心臟與血管的刺激，進而心跳速率下降、心輸出量減少，使週邊血管阻力與循環負荷下降。

​Reference(s):

1. Piletz JE et al. (1993). Nonadrenergic imidazoline binding sites on human platelets. J Pharmacol Exp Ther. 


2. Bockman CS et al. (1993). Binding and functional characterization of alpha-2 adrenergic receptor subtypes on pig vascular endothelium. J Pharmacol Exp Ther. 


3. Bockman CS et al. (1996). Alpha-2 adrenoceptor subtype causing nitric oxide-mediated vascular relaxation in rats. J Pharmacol Exp Ther.

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