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The Sound of Evolution
Guanadrel
胍環定
Mechanism of action:
Guanadrel 是一種腎上腺素神經元阻斷劑（adrenergic neuron blocker）。Guanadrel 在交感神經元內會累積於神經末梢與儲存囊泡附近，逐步取代囊泡中的正腎上腺素（norepinephrine），使可釋放的正腎上腺素儲量下降。當神經受到刺激時，由於正腎上腺素儲存不足且釋放受阻，交感神經對心臟與血管的刺激明顯減弱，使週邊血管張力與心臟交感驅動下降。
Reference(s):
1. Malinow SH et al. (1983). Comparison of guanadrel and guanethidine efficacy and side effects. Clin Ther.
2. Finnerty FA Jr et al. (1985). Guanadrel. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in hypertension. Drugs.
3. Palmer JD et al. (1983). Guanadrel sulfate: a postganglionic sympathetic inhibitor for the treatment of mild to moderate hypertension. Pharmacotherapy.
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