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Heparin

肝素

Mechanism of action:

Heparin 是一種硫酸化糖胺聚醣類（sulfated glycosaminoglycan）。Heparin 透過與抗凝血酶（antithrombin；舊稱 antithrombin III）結合並增強其活性，使其抑制凝血因子 Xa（factor Xa）及凝血酶（thrombin）的活性，進而阻止凝血酶原（prothrombin）轉變為凝血酶，減少纖維蛋白（fibrin）形成，降低血栓形成與擴大的風險。

​Reference(s):

1. Linhardt RJ et al. (1999). Production and chemical processing of low molecular weight heparins. Semin Thromb Hemost. 


2. Ferro DR et al. (1990). Conformer populations of L-iduronic acid residues in glycosaminoglycan sequences. Carbohydr Res. 


3. Mulloy B et al. (1993). N.m.r. and molecular-modelling studies of the solution conformation of heparin. Biochem J.

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