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The Sound of Evolution
Hydralazine
肼屈嗪
Mechanism of action:
Hydralazine 的明確機制還不清楚，但可能是透過影響平滑肌細胞內鈣離子動態（例如降低細胞內 Ca²⁺ 可用性，包含抑制 IP₃ 介導的鈣離子釋放等途徑），降低細胞質鈣離子濃度，使平滑肌無法有效收縮，導致血管擴張。
Reference(s):
1. Hofstra AH et al. (1994). Metabolism of hydralazine: relevance to drug-induced lupus. Drug Metab Rev.
2. Bolattin M et al. (2016). Interaction of hydralazine with human serum albumin and effect of β-cyclodextrin on binding: insights from spectroscopic and molecular docking techniques. Ind Eng Chem Res.
3. Machado JD et al. (2002). Hydralazine reduces the quantal size of secretory events by displacement of catecholamines from adrenomedullary chromaffin secretory vesicles. Circ Res.
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