top of page
< Back

Ibandronate

伊班膦酸

Mechanism of action:

Ibandronate 是一種含氮雙磷酸鹽（nitrogen-containing bisphosphonate）衍生物。Ibandronate 會選擇性結合於骨表面的羥磷灰石，特別集中在骨吸收活躍的部位。當破骨細胞（osteoclast）進行骨吸收時，ibandronate 會隨骨基質被破骨細胞吞入細胞內。Ibandronate 在破骨細胞內會抑制法尼基焦磷酸合酶（farnesyl pyrophosphate synthase），阻斷異戊二烯化（prenylation）所需的中間產物生成。當小型 GTP 結合蛋白（如 Ras、Rho、Rab）無法進行異戊二烯化（prenylation）時，破骨細胞的多種代謝會受到抑制，最終導致破骨細胞凋亡。

​Reference(s):

1. Cremers S et al. (2019). Pharmacology of bisphosphonates. Br J Clin Pharmacol. 


2. Monier-Faugere MC et al. (1993). A new bisphosphonate, BM 21.0955, prevents bone loss associated with cessation of ovarian function in experimental dogs. J Bone Miner Res. 


3. Cao R et al. (2008). Structures of a potent phenylalkyl bisphosphonate inhibitor bound to farnesyl and geranylgeranyl diphosphate synthases. Proteins.

bottom of page