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Indinavir

因地那韋

Mechanism of action:

Indinavir 是一種 HIV 蛋白酶抑制劑（HIV protease inhibitor）。HIV 病毒的蛋白酶負責將病毒前驅多蛋白 Gag 與 Gag-Pol 切割為功能性結構蛋白與酵素。Indinavir 會與蛋白酶的活性位點高親和力結合，競爭性抑制其酵素活性，使形成的病毒顆粒為未成熟且不具感染能力。

​Reference(s):

1. Wittayanarakul K et al. (2008). Accurate prediction of protonation state as a prerequisite for reliable MM-PB(GB)SA binding free energy calculations of HIV-1 protease inhibitors. J Comput Chem. 


2. Dandache S et al. (2007). In vitro antiviral activity and cross-resistance profile of PL-100, a novel protease inhibitor of human immunodeficiency virus type 1. Antimicrob Agents Chemother.

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