top of page
The Sound of Evolution
Indomethacin
吲哚美辛
Mechanism of action:
Indomethacin 是一種吲哚乙酸類（indoleacetic acid）衍生物。Indomethacin 能抑制環氧化酶（cyclooxygenase），包含 COX-1 與 COX-2，阻止將花生四烯酸（arachidonic acid）轉換為前列腺素（prostaglandin），降低前列腺素介導的發炎訊號、疼痛敏感化與發燒反應。
Reference(s):
1. Lucas S et al. (2016). The pharmacology of indomethacin. Headache.
2. Helleberg L et al. (1981). Clinical pharmacokinetics of indomethacin. Clin Pharmacokinet.
3. Nalamachu S et al. (2014). Role of indomethacin in acute pain and inflammation management: a review of the literature. Postgrad Med.
bottom of page