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Irbesartan

厄貝沙坦

Mechanism of action:

Irbesartan 是一種血管張力素 II 受體阻斷劑（angiotensin II receptor blocker）。血管張力素 II（angiotensin II）原本會透過 AT₁ 受體促使血管平滑肌收縮，使血壓上升。Irbesartan 阻斷 AT₁ 受體後，使週邊血管擴張，降低全身血管阻力，降低血管張力素 II 介導的升壓訊號。

​Reference(s):

1. Lewis EJ et al. (2001). Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes. N Engl J Med. 


2. Croom KF et al. (2004). Irbesartan: a review of its use in hypertension and in the management of diabetic nephropathy. Drugs. 


3. Chando TJ et al. (1998). Biotransformation of irbesartan in man. Drug Metab Dispos.

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