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Isoflurane

異氟烷

Mechanism of action:

Isoflurane 是一種鹵化醚類（halogenated ether）衍生物。Isoflurane 可正向調節 GABA_A 受體與甘胺酸（glycine）受體，增加氯離子內流，使神經元產生超極化（hyperpolarization），降低神經元放電活性。Isoflurane 也抑制 NMDA 受體活性，降低突觸前神經傳導物質釋放，使神經網路整體興奮度下降。

​Reference(s):

1. McCracken ML et al. (2010). A transmembrane amino acid in the GABAA receptor beta2 subunit critical for the actions of alcohols and anesthetics. J Pharmacol Exp Ther. 


2. Seo K et al. (2010). Genetic reduction of GABA(A) receptor gamma2 subunit expression potentiates the immobilizing action of isoflurane. Neurosci Lett.

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