The Sound of Evolution
Isoflurophate
二異丙基氟磷酸
Mechanism of action:
Isoflurophate 是一種有機磷類膽鹼酯酶抑制劑（organophosphate cholinesterase inhibitor）。Isoflurophate 會與乙醯膽鹼酯酶（acetylcholinesterase）的活性位點形成穩定的磷酸化共價鍵，阻止乙醯膽鹼（acetylcholine）被分解，使乙醯膽鹼在突觸間隙濃度顯著上升。乙醯膽鹼累積後，會持續活化毒蕈鹼型乙醯膽鹼受體（muscarinic acetylcholine receptor），導致瞳孔括約肌收縮，瞳孔縮小（miosis）；睫狀肌收縮，增加房水外流，降低眼內壓。
Reference(s):
1. Malatova Z et al. (1999). Depression of acetylcholinesterase synthesis following transient cerebral ischemia in rat: pharmacohistochemical and biochemical investigation. Gen Physiol Biophys.
2. Quistad GB et al. (2000). Phosphoacetylcholinesterase: toxicity of phosphorus oxychloride to mammals and insects that can be attributed to selective phosphorylation of acetylcholinesterase by phosphorodichloridic acid. Chem Res Toxicol.
3. da Costa VL Jr et al. (2001). Short- and long-term influences of calcitonin gene-related peptide on the synthesis of acetylcholinesterase in mammalian myotubes. Br J Pharmacol.