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Ketorolac

酮咯酸

Mechanism of action:

Ketorolac 是一種吡咯乙酸（pyrroloacetic acid）衍生物。Ketorolac 能抑制環氧化酶（cyclooxygenase），包含 COX-1 與 COX-2，阻止將花生四烯酸（arachidonic acid）轉換為前列腺素（prostaglandin），降低前列腺素介導的發炎訊號與疼痛敏感化。

​Reference(s):

1. Brocks DR et al. (1992). Clinical pharmacokinetics of ketorolac tromethamine. Clin Pharmacokinet. 


2. Litvak KM et al. (1990). Ketorolac, an injectable nonnarcotic analgesic. Clin Pharm. 


3. Macario A et al. (2001). Ketorolac in the era of cyclo-oxygenase-2 selective nonsteroidal anti-inflammatory drugs: a systematic review of efficacy, side effects, and regulatory issues. Pain Med.

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