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The Sound of Evolution
Labetalol
拉貝洛爾
Mechanism of action:
Labetalol 是一種 α 與 β 腎上腺素受體阻斷劑（α/β-adrenergic receptor blocker），同時具有 β 受體阻斷作用為主、α₁ 受體阻斷作用為輔的特性。Labetalol 能阻斷心血管的 β₁ 受體，降低心跳速率與心肌收縮力，使心輸出量下降。阻斷 β₂ 受體，減少交感神經介導的血管與支氣管擴張作用，但在 labetalol 中此效應相對次要。Labetalol 也能阻斷 α₁ 受體，抑制血管平滑肌收縮，造成週邊血管擴張，降低全身血管阻力，使血壓降低。
Reference(s):
1. Yeleswaram K et al. (1993). Disposition, metabolism, and pharmacodynamics of labetalol in adult sheep. Drug Metab Dispos.
2. McNeil JJ et al. (1984). Clinical pharmacokinetics of labetalol. Clin Pharmacokinet.
3. Opie LH et al. (1988). Role of vasodilation in the antihypertensive and antianginal effects of labetalol: implications for therapy of combined hypertension and angina. Cardiovasc Drugs Ther.
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